Rybelsus (Oral semaglutide) plotter

Rybelsus. Same ~7 day half-life as injectable semaglutide but taken daily. The plot is remaining milligrams of the tablet dose, not equivalent exposure to a 2.4 mg injection.

t½ 7dTmax 1d100% parentGLP-1mg

Also called Oral semaglutide.

Compare with Ozempic.

FDA Rybelsus label: half-life ~1 week; daily oral dosing.

Your cycle

Dose, ester, and frequency. The chart is remaining active amount, not serum concentration. To step a dose up, add another row of the same compound with a later start day.

Compound 1

t½ 7dTmax 1d100% parent

Dose (mg)

Frequency

Start day

Duration (weeks)

Per-compound linesTotal line

Peaks, troughs, and half-life

Estimated remaining active mg. Washout continues after the last dose. Mixed IU and mg protocols are not summed.

Oral semaglutide

Peak

31.7 mg

Trough

31.7 mg

Swing

~Steady state

35d

~Washout

36d

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